How Does Zubsolv Work?
Zubsolv works by interacting with opioid receptors. It contains buprenorphine, which binds to the opioid receptors, and naloxone, a drug that essentially inhibits the euphoria response. The combination of the two drugs prevents withdrawal symptoms from emerging but does not provide a high similar to a prescription opioid.
The half-life of Zubsolv depends on that of buprenorphine, which is 24–48 hours. For that reason, Zubsolv is taken once a day to maintain levels of buprenorphine in the patient.
How long Zubsolv blocks opiates, depends on the half-life of naloxone, which is only 30–60 minutes.
Does Zubsolv Get You High?
Because Zubsolv binds to the same receptors as opioids, you may be wondering, “Can you get high on Zubsolv?” Because it stimulates the same receptors as opioids, Zubsolv can cause feelings of euphoria, similar to opioids. However, the Zubsolv high is less intense than that of other opioids or illicit drugs because it only partially binds the receptor. Additionally, buprenorphine in Zubsolv has a “cap effect,” meaning that at a certain point it will reach a limit where no more can bind to the receptors and, therefore, there is no change in the reaction that a person feels. No matter how much more they take, no additional high will be achieved. This is part of the reason it works so well as a treatment for opioid addiction.