Methadone is an opioid that is commonly prescribed to treat severe pain or help people who are experiencing opioid withdrawal symptoms. Methadone use disorder is associated with several physical and psychological side effects that can help identify someone who is struggling with methadone dependence. People can recognize addiction early and get help by understanding the signs and symptoms of methadone use, signs of overdose and options for treating methadone addiction. How Is Methadone Abused? Like all opioids, methadone use carries the risk of dependence or addiction. Many people who use methadone had legitimate opioid prescriptions at one point, but they were unable to stop using opioids when their prescription ran out. Methadone abuse can be done by ingesting pills or liquid solutions, injecting the drug, smoking or snorting. There are legitimate long-term uses for methadone in some cases. While methadone can cause addiction, it is far less addictive than opioids like heroin, fentanyl, oxycodone and morphine. When someone uses powerfully addictive opioids, substantial changes in brain chemistry occur rapidly. The effects can last for years and can be incredibly debilitating. Methadone has similar physical effects in the brain but lacks the euphoric high that is associated with other opioids. For people who struggle with opioid addiction, methadone can replace the opioid they used in the past to get high. Methadone essentially tricks the brain into thinking that it has its drug of choice, but methadone doesn’t have the powerful reinforcing effects that the opioid high delivers. For people with a debilitating opioid addiction, methadone can offer a way to reintegrate into society, maintain gainful employment and develop healthy relationships. In these cases, methadone maintenance treatment can be lifesaving. However, people must take it as prescribed and under the direct care of medical professionals. Methadone Addiction Signs Like most addiction disorders, people who struggle with methadone use disorder will likely experience behavioral changes, including: Loss of interest in hobbies Irresponsibility Isolationism Rapid mood swings Inability to focus or complete tasks Lethargy Methadone Side Effects When used as directed, methadone side effects are typically mild. However, high doses are associated with a sense of euphoria and sedation, especially in people who have not struggled with prior opioid dependency. Effects of methadone on the body are physical as well as mental. Physical Effects Some of the physical side effects of methadone are: Weight gain: Most people who report weight gain after methadone are involved in methadone maintenance treatment programs. As they begin to make healthy lifestyle choices, their weight may go up. Evidence also suggests that opioid use (including methadone) is associated with increased sugar intake, which can lead to weight gain. Constipation: Opioids, including methadone, can cause constipation. In fact, an opium derivative called laudanum was the earliest known treatment for diarrhea, dating back to the 15th century. While opioid receptors are most commonly associated with the brain, there is also an opioid receptor network in the gut. Methadone use affects gut contraction in two ways: direct action in the gut and indirect action through the brain. Both actions reduce gut contraction and lead to constipation. Opioids also cause increased fluid absorption in the gut, which causes stools to harden. Tiredness: Tiredness and fatigue are non-specific symptoms that are reported by some methadone users. Opioids are central nervous system depressants (sedatives), so reduced energy levels are common, especially with high doses. Chronic methadone users or people in maintenance treatment programs are more likely to report daytime sleepiness that affects normal daily function. This could be due to an opioid-induced adrenal insufficiency, where hormone production is slowed. However, the precise relationship between methadone use and fatigue remains unclear. Tooth problems: Methadone use is associated with poor oral health. There are likely multiple contributors to this, including dry mouth. A dry mouth can make teeth prone to plaque production, which promotes gum decay. Sugar-based liquid methadone formulations can also cause dental issues. Mental Effects One of the reasons why methadone is effective in treating opioid addiction and withdrawal is that it has few substantial psychological effects. It effectively tricks the brain into believing that powerful opioid narcotics like heroin or fentanyl have been ingested. With methadone, though, the user does not experience the euphoria that is associated with heroin and fentanyl. High doses of methadone, however, can cause mild euphoria in people who take it for pain management and do not have dependency. Long-term effects of methadone on the brain are still being evaluated. Mounting evidence suggests that chronic methadone use can affect more than opioid receptors and reward centers in the body. The effects may depend on what methadone is being used to treat. A study was done on people who used methadone maintenance therapy for heroin addiction. It found that cognitive performance increased over time, but the integrity of white matter in the brain decreased. However, people with methadone use disorder who originally took it for pain management have a much higher risk for negative outcomes on brain structure and function. In addition, methadone-induced brain changes are more profound in adolescents and young adults, whose brains are still developing. Young people in particular should never be prescribed methadone for long-term pain management. Seeking Treatment for Methadone Abuse? Whether you're calling for yourself or a loved one, our Intake Coordinators are here to help. Your call is confidential, and there's no pressure to commit to treatment until you're ready. We are ready and waiting to answer your questions or concerns 24/7. 561-582-2030 Methadone Abuse Facts and Statistics Methadone use is increasing in the U.S. The number of people in methadone maintenance treatment programs increased 37% between 2003–2015. Methadone misuse is substantially lower than misuse associated with other opioids that are prescribed for pain management. Statistics show that only 0.1% of people aged 12 or older misused methadone within the past year, compared to 4.3% for hydrocodone and 2.6% for oxycodone. Methadone Abuse and Treatment Trends in South Florida According to the National Early Drug Warning System, methadone-related deaths in South Florida declined by approximately 5% between 2011–2015. Of all deaths associated with opioids, only 2.8% were linked to methadone in 2016 (23 methadone-related deaths out of a total of 827 opioid-related deaths). Seizures of illicit methadone are also rare. In 2016, methadone seizures by Miami law enforcement made up only 0.7% of opioid seizures and 0.1% of total drug seizures. This suggests that methadone misuse is declining in South Florida. However, it is important to note that reliable statistics for substance use disorders are difficult to obtain. Low rates of illicit methadone seizures do not necessarily reflect low levels of methadone misuse. Methadone Overdose Symptoms Methadone overdose is a medical emergency that can lead to death. Methadone is a central nervous system depressant that can lead to respiratory depression, low blood pressure, coma or death. Symptoms of methadone overdose include: Nausea or vomiting Dizziness Disorientation Profound lethargy Confusion Muscle twitching or weakness Hypothermia If you suspect a methadone overdose, call 911 immediately. How to Get Off Methadone Most medical professionals recommend tapering off of methadone. Like other opioids, methadone withdrawal is associated with uncomfortable side effects that can be somewhat reduced by tapering the dose. The initial days or weeks after reducing or quitting methadone can be difficult. Many people have the most success by undergoing detox and withdrawal under the supervision of medical professionals at a detox facility. Staff members can address concerns and provide medication to help with withdrawal if necessary. Resources for people with methadone use disorder include: Detoxing off methadone: The detox period can be uncomfortable. Withdrawal symptoms typically include nausea or vomiting, sweating, anxiety, irritability and lack of pleasure. Methadone clinics: Methadone clinics provide daily doses of methadone to people who are in recovery from heroin or other opioid use disorders. A methadone clinic can be a valuable stepping stone for people who are in recovery. Outpatient: Outpatient rehab is an important component of recovery. Some people with mild dependency issues may find that outpatient rehab is enough, but most people will enter an outpatient program after a period of residential care. Outpatient programs vary quite a bit, ranging from daily to weekly sessions. The goal of outpatient rehab is to give clients an opportunity to begin a sober lifestyle while maintaining a strong support network that can help clients avoid triggers and relapse. Dual diagnosis: Underlying mental health issues are a component of substance use disorders. Many people use drugs to mask emotional issues or past trauma. A dual diagnosis can help clients understand if they are using substances as a way to avoid dealing with disorders such as anxiety, depression or PTSD. Our Drug Detox and Inpatient Rehab Center The Recovery Village Palm Beach at Baptist Health 4905 Lantana Rd Lake Worth, FL 33463 561-340-7269v Key Points: Understanding Methadone Addiction and Abuse Methadone is associated with a risk for developing dependence or addiction. It is important to remember these key points about methadone misuse: Methadone misuse often causes a loss of interest in normal activities, irresponsible behavior, inability to concentrate and sudden mood swings Physical effects of methadone misuse can include weight gain, dizziness, constipation, nausea/vomiting, itchy skin and dental problems Psychological effects of methadone misuse can include anxiety, irritability, decreased sexual desire and lethargy Methadone overdoses can cause respiratory depression, slow or rapid heart rate, coma and death Methadone misuse has decreased as methadone prescriptions become more difficult to get, but accurate statistics are rare Methadone treatment typically involves a period of detox and withdrawal, followed by residential and outpatient care Many substance use disorders are associated with underlying mental health issues or past traumas. A dual diagnosis often identifies factors that contribute to substance misuse. Methadone clinics typically provide methadone to people who struggle with heroin, fentanyl, oxycodone or morphine addiction. Methadone has similar effects as these drugs but does not lead to euphoria when taken as prescribed. Methadone should only be used as directed and should never be given away If you or a loved one is struggling with addiction to methadone, The Recovery Village Palm Beach at Baptist Health can help. Contact us today to learn more about treatment plans that can work well for you. SourcesDrugs.com. “Methadone.” August 2019. Accessed August 2, 2019. MedlinePlus. “Methadone overdose.” September 2017. Accessed August 2, 2019. World Health Organization. “Clinical Guidelines for Withdrawal Management and Treatment of Drug Dependence in Closed Settings: Methadone Maintenance Treatment.” 2009. Accessed August 2, 2019. Fenn, Jennifer M.; Laurent, Jennifer S.; Sigmon, Stacey C. “Increases in body mass index following initiation of methadone treatment.” The Journal of Substance Abuse Treatment, November 2014. Accessed August 2, 2019. Mysels, David J.; Sullivan, Maria A. “The relationship between opioid and sugar intake: Review of evidence and clinical applications.” The Journal of Opioid Management, December 2010. Accessed August 2, 2019. Holzer, Peter. “Opioid receptors in the gastrointestinal tract.” Regulatory Peptides, June 2009. Accessed August 2, 2019. Sizar, Omeed; Gupta, Mohit. “Opioid Induced Constipation.” NCBI StatPearls, June 2019. Accessed August 2, 2019. Wang, David; Teichtahl, Harry; Goodman, Cathy; Drummer, Olaf; Grunstein, Ronald R.; Kronborg, Ian. “Subjective Daytime Sleepiness and Daytime Function in Patients on Stable Methadone Maintenance Treatment: Possible Mechanisms.” Journal of Clinical Sleep Medicine, May 2008. Accessed August 2, 2019. Lee, Angela S.; Twigg, Stephen M. “Opioid-induced secondary adrenal insufficiency presenting as hypercalcaemia.” Endocrinology, Diabetes & Metabolism Case Reports, June 2015. Accessed August 2, 2019. Green, Robert; Pynn, Bruce R. “Methadone: A Review.” Oral Health, June 2011. Accessed August 2, 2019. University of Maryland. “Methadone.” Center for Substance Abuse Research, January 2016. Accessed August 2, 2019. Motlagh, Farid; Ibrahim, Fatimah; Rashid, Rusdi; Shafiabady, Niusha; Seghatoleslam, Tahereh; Habil, Hussain. “Acute effects of methadone on EEG power spectrum and event-related potentials among heroin dependents.” Psychopharmacology, November 2018. Accessed August 2, 2019. Li, Wei; Li, Qiang; Wang, Yarong; Zhu, Jia; Ye, Jianjun; Yan, Xuejiao; Li, Yongbin; Chen, Jiajie; Liu, Jierong; Li, Zhe; Wang, Wei; Liu, Yijun. “Methadone-induced Damage to White Matter Integrity in Methadone Maintenance Patients: A Longitudinal Self-control DTI Study.” Scientific Reports, January 2016. Accessed August 2, 2019. Vestal-Laborde, Allison A.; Eschenroeder, Andrew C.; Bigbee, John W.; Robinson, Susan E.; Sato-Bigbee, Carmen. “The opioid system and brain development: methadone effects on the oligodendrocyte lineage and the early stages of myelination.” Developmental Neuroscience, August 2014. Accessed August 2, 2019. Alderks, Cathie E. “Trends in The Use Of Methadone, Buprenorphine, And Extended-Release Naltrexone At Substance Abuse Treatment Facilities: 2003-2015 (Update).” Substance Abuse and Mental Health Services Administration. August 2017. Accessed August 3, 2019. Faul, Mark; Bohm, Michele; Alexander, Caleb. “Methadone Prescribing and Overdose and the Association with Medicaid Preferred Drug List Policies – United States, 2007-2014.” Centers for Disease Control and Prevention Morbidity and Mortality Weekly Report, March 2017. Accessed August 3, 2019. Substance Abuse and Mental Health Services Administration. “Key substance use and mental health indicators in the United States: Results from the 2016 National Survey on Drug Use and Health.” September 2017. Accessed August 3, 2019. National Early Drug Warning System. “Southeastern Florida (Miami Area) Sentinel Community Site (SCS) Drug Use Patterns and Trends, 2017.” November 2017. Accessed August 3, 2019. Medical Disclaimer: The Recovery Village aims to improve the quality of life for people struggling with a substance use or mental health disorder with fact-based content about the nature of behavioral health conditions, treatment options and their related outcomes. We publish material that is researched, cited, edited and reviewed by licensed medical professionals. The information we provide is not intended to be a substitute for professional medical advice, diagnosis or treatment. It should not be used in place of the advice of your physician or other qualified healthcare provider.