Differences Between Lyrica and Gabapentin
Despite being similar drugs believed to work in similar ways, pregabalin and gabapentin have some differences. These include differences in their side effects, doses and effectiveness in treating several different medical conditions.
Lyrica vs. Gabapentin Side Effects
Pregabalin and gabapentin share many common side effects because they are both central nervous system depressants that likely act in similar ways on the brain.
Common pregabalin side effects include:
- Dizziness
- Sleepiness
- Dry mouth
- Swelling
- Blurred vision
- Weight gain
- Attention and concentration problems
Similarly, gabapentin side effects include:
- Dizziness
- Sleepiness
- Movement difficulties
- Fatigue
- Swelling
- Rapid eye movements
Lyrica vs. Gabapentin Dosage
Pregabalin and gabapentin are both given by mouth in several different dosage forms and amounts. Both drugs rely on good kidney function to clear them from your system, so a person with poor kidney function may take lower doses of the drug. Pregabalin doses are lower than gabapentin doses because pregabalin is about six times more potent than gabapentin.
Pregabalin is usually taken twice daily, although the extended-release tablet is taken once daily. The drug is available in the following doses and dosage forms:
Capsules: 25mg, 50mg, 75mg, 100mg, 150mg, 200mg, 225mg, 300mg
Oral Liquid: 20mg per milliliter
Extended-Release Tablets: 82.5mg, 165mg, 330mg
Gabapentin is usually taken two or three times daily and is best absorbed when taken with food. However, the extended-release tablet form of the drug may be given only once daily. It is available in the following doses and dosage forms:
Capsules: 100mg, 300mg, 400mg
Oral Liquid: 250mg per 5 milliliters
Tablets: 100mg, 300mg, 400mg, 600mg, 800mg
Extended-Release Tablets: 300mg, 600mg
Lyrica vs. Gabapentin Effectiveness
Pregabalin and gabapentin are both effective drugs for treating several different health conditions. Few studies have been conducted directly comparing the two drugs, and the studies that have been done have conflicting findings. For example, one study on spinal cord injury nerve pain found pregabalin was more effective than gabapentin and had fewer side effects. However, another study found no difference between the two treatments or side effects when used for spinal cord injury nerve pain. More studies would likely need to be conducted to get a clearer picture of whether one drug is better and safer than the other.
Lyrica vs. Gabapentin for Anxiety
Neither pregabalin nor gabapentin is the first-line treatment for anxiety, which is generally treated with a combination of antidepressants and therapy. However, in some cases, experts say pregabalin can be used at a total daily dose of 150 mg–600 mg. Gabapentin, on the other hand, is not a recommended therapy.
Lyrica vs. Gabapentin for Fibromyalgia
Pregabalin is one of the main treatments often used alongside non-drug therapies to treat fibromyalgia. It has been studied at a total daily dose of 450 mg to treat the condition. Although gabapentin has also been studied for fibromyalgia, its use is currently limited to research.
Lyrica vs. Gabapentin for Nerve Pain
Both pregabalin and gabapentin are commonly prescribed to treat several different causes of nerve pain, including post-shingles and diabetic nerve pain. Although several studies indicated that pregabalin might be more effective than gabapentin with fewer side effects when used for nerve pain, not all studies agree. One recent study found that gabapentin was more effective than pregabalin for nerve pain caused by sciatica and caused fewer side effects.
Lyrica vs. Gabapentin Withdrawal Symptoms
Because physical dependence can occur when pregabalin or gabapentin are taken regularly, the doses of both drugs should be lowered slowly instead of stopping cold turkey. Both drugs should be tapered over at least a week to avoid pregabalin and gabapentin withdrawal symptoms like:
- Trouble sleeping
- Nausea
- Headache
- Diarrhea
- Anxiety
- Sweating