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DMT Overdose

Written by Rob Alston

& Medically Reviewed by Dr. Trisha Sippel, PhD

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Last Updated - 1/19/2021

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Updated 01/19/2021


DMT is a powerful hallucinogenic drug. While overdosing on DMT is not the same as with other hallucinogenic drugs, taking too much can have negative effects.

N-N-dimethyltryptamine, also known as DMT, is a powerful psychedelic drug that has traditionally been used by Amazonian tribes, but its use recreationally in the United States is on the rise. Dimethyltryptamine is found in a wide variety of plants and is also a natural chemical found in most animals. Only when it is taken in excess, to increase its concentration to higher than normal in the body, does it have a psychedelic effect.

The effects of taking DMT are similar to that of hallucinogenic drugs like LSD. It causes intense visual hallucinations. Some people have described a DMT drug trip as similar to a near-death experience, where they feel like they are leaving their body and experiencing an alternate universe. Some people also report seeing or communicating with a ‘presence’ or entity that isn’t really there.

These experiences can cause a sense of euphoria that people want to experience more than once. Due to the high potential for abuse and lack of medical use, DMT is considered a Schedule I controlled substance by the DEA and its use is illegal in the United States. Despite this, it is legal for use by some religious and spiritual groups. Though it is not considered as dangerous as some of the other Schedule I drugs, it can still cause an overdose if too much is consumed.

Can You Overdose On DMT?

Overdoses are caused by a person taking too much of a drug, to the point that it is toxic. Since it is only used recreationally, there is not a specified DMT dosage. When determining how much DMT to take, people will adjust based on the route of administration they are using. As stated, DMT taken orally will not have an effect since it is broken down quickly. To be taken orally, it needs to be mixed with a monoamine oxidase inhibitor (MAOI), which will inhibit its rapid degradation. To get around this, DMT is sometimes smoked or injected. When taken this way, it can have rapid effects (within seconds to minutes) and only lasts for 15–60 minutes.

When taken with a MOAI the effects take longer to kick in (up to 60 minutes) but last for up to four hours.

With other types of drugs, this inconsistency in dosing could lead to an overdose, where the person takes too much and it has detrimental health effects. However, DMT is generally well tolerated, with only a few reports of it having acute cardiovascular effects. So far research on DMT has not found any long-term health risks associated with DMT use. Most literature on DMT agrees that there is not enough evidence to suggest that it is toxic, even in high amounts.

DMT Overdose Symptoms

Though DMT is generally well tolerated, there are side effects that can occur from using the drug. When taken with other substances to inhibit its rapid degradation, such as an MAOI, it may be difficult to determine if the side effects are from DMT or the other substance. Nevertheless, aside from the psychedelic effects, the DMT drug side effects include:

DMT Side Effects

  • Nausea
  • Vomiting
  • High blood pressure
  • Faster than normal heart rate
  • Pupil dilation
  • Becoming agitated

An overdose occurs when someone takes too much of a drug and it essentially shuts down the body’s normal functions. This occurs at different doses with different types of drugs, depending on how potent the drug is affecting these normal bodily functions. DMT doesn’t often cause this type of reaction since the chemical doesn’t appear to affect normal bodily functions as much as some other hallucinogens. Instead, overdosing on DMT can lead to psychological effects, when the person has a negative experience with the hallucinations. This is sometimes referred to as a bad DMT trip. However, while it is not common, DMT drug overdose has been fatal in very rare cases.

DMT Overdose Treatment

Since DMT use is not generally considered toxic, there is not a standard treatment for a DMT overdose treatment, as there are for other types of illicit drugs. The effects of the DMT drug are primarily psychological and a person may need to get help after experiencing a bad DMT trip. Most overdoses occur as a result of developing tolerance to a drug, causing the person to take more and more of the drug until it becomes toxic to them. DMT does not cause tolerance and therefore people generally do not have to change or increase the dosage to get the same effect, making the risk of overdosing low.

Most people who take DMT will not become physically dependent on it, but it can occur with other drugs, however, it is possible to become addicted to the psychedelic effects that it has. If a person is using DMT continually for these effects, to the point where it is interfering with their everyday life, they may need DMT addiction treatment.

View Sources

Palamar, Joseph J.; Le, Austin. “Trends in DMT and Other Tryptamine Use Among Young Adults in the United States.” The American Journal on Addictions, October, 2018. Accessed October 25, 2019.

Timmermann, Christopher; Roseman, Leor; Williams,Luke; Erritzoe, David; Martial, Charlotte; Cassol, Héléna; Laureys, Steven; Nutt, David; Carhart-Harris, Robin. “DMT Models the Near-Death Experience.” Frontiers in Psychology, August 15, 2018. Accessed October 25, 2019.

Drug Enforcement Administration. “N,N-DIMETHYLTRYPTAMINE (DMT).” July, 2019. Accessed October 25, 2019.

Barker, Steven A. “N, N-Dimethyltryptamine (DMT), an Endogenous Hallucinogen: Past, Present, and Future Research to Determine Its Role and Function.” Frontiers in Neuroscience, August 6, 2018. Accessed October 25, 2019.

Carbonaro, Theresa M.; Gatch, Michael B. “Neuropharmacology of N,N-Dimethyltryptamine.” Brain Research Bulletin, September 1, 2017. Accessed October 25, 2019.

Heise, C. William; Brooks, Daniel E. “Ayahuasca Exposure: Descriptive Analysis of Calls to US Poison Control Centers from 2005 to 2015.” The Journal of Medical Toxicology, September, 2017. Accessed October 25, 2019.

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