Seasonal allergies can make you miserable. Fortunately, symptoms like sneezing, runny nose, eye irritation and itching can be relieved by some over-the-counter allergy medications. One such medication is Claritin. Although the package labeling on Claritin does not mention if it is safe to drink alcohol while using the medication, experts believe you should avoid mixing the two substances. Mixing Alcohol and Claritin vs. Claritin-D Claritin and Claritin-D are similar drugs. Claritin is the brand name for the generic drug loratadine, a once-daily antihistamine that is FDA-approved to treat and prevent allergy symptoms. Similarly, Claritin-D contains loratadine as well as pseudoephedrine, an over-the-counter decongestant. Claritin-D is a once- and twice-daily drug that is FDA-approved to treat allergy symptoms as well as nasal stuffiness from the common cold. You should use caution if mixing either Claritin or Claritin-D with alcohol. The drug interaction between loratadine and alcohol, with or without pseudoephedrine, raises concerns about additive side effects and safety. Even if you try to space out your dose of Claritin or Claritin-D with your drinking, there is still a risk of side effects. This is because loratadine is a very long-acting drug that takes a long time to leave your body, especially if you have kidney or liver problems or are a senior citizen. In adults without liver problems, loratadine has a half-life of 8.4 hours, meaning that it takes 8.4 hours to clear half of a single dose from your body. Since it takes around five half-lives for a drug to completely leave your system, loratadine can remain present in your body for more than 40 hours. Intense Drowsiness Most antihistamines are central nervous system depressants and can be sedating. Although loratadine is less sedating than some other antihistamines, drowsiness and dizziness are still possible side effects, especially when the drug is mixed with alcohol. Impaired Judgment Impaired judgment is a side effect of drinking. When you mix alcohol with Claritin, the central nervous system effects of both drugs may be additive. In turn, your judgment may be impaired more than normal while drinking. Increased Risk of Alcohol Overdose Although little data exists on mixing alcohol and Claritin, it is known that drinking can be dangerous if you take stimulants. This is because stimulants, such as caffeine, counteract the sleepy feeling you get when you have had too much alcohol, leading you to drink more than you may have otherwise. Although loratadine itself is not a stimulant, the pseudoephedrine that is also present in Claritin-D is a stimulant. Therefore, it is possible that the stimulant action of pseudoephedrine may put you at risk for excessive drinking. Decreased Effectiveness of Claritin Alcohol can cause dehydration, both through its diuretic action (increased urination) as well as from nausea and vomiting due to drinking too much. In turn, dehydration can intensify allergy symptoms and counteract Claritin. This may be especially true of Claritin-D, which contains the decongestant pseudoephedrine that can further dry out nasal membranes. Reducing Alcohol Intake May Reduce Allergy Symptoms Dehydration, a side effect of drinking, can worsen allergy symptoms. This occurs because dehydration increases the amount of histamine your body produces. Histamine is released by mast cells in your body when you encounter allergens. By avoiding alcohol and dehydration, your body produces less histamine, meaning that your allergy symptoms are less severe. Further, alcohol can induce allergy symptoms in some people. Beer can contain gluten, yeast, hops, barley and grapes, which can all be allergens. Wine may also contain substances that can induce reactions in people with tree nut, dairy, egg and fish allergies. Both beer and wine may also contain a chemical called sodium metabisulfite, a preservative that may exacerbate allergic conditions like asthma. Avoiding drinking may help you prevent reactions to these substances. About Alcohol AbuseAlcohol AddictionAlcohol Abuse TreatmentAlcohol Withdrawal & DetoxSee More Getting Help for Alcohol Abuse If you or a loved one struggle with drinking, you do not have to face your addiction alone. Our alcohol addiction experts at The Recovery Village at Baptist Health can help you get started on your road to a new, alcohol-free life. Contact us today to learn more about treatment programs that can work well for your situation and needs. SourcesHobson, Ruth M; Maughan, Ronald J. “Hydration Status and the Diuretic Action of a Small Dose of Alcohol.” Alcohol and Alcoholism, August 2010. Accessed October 18, 2020. Cohen, Paula. “Allergy survival guide: 10 tips from a top doctor.” CBS News, May 15, 2015. Accessed October 18, 2020. Centers for Disease Control and Prevention. “Alcohol and Caffeine.” February 4, 2020. Accessed October 18, 2020. Spence, Angela L; Sim, Marc; Landers, Grant; Peeling, Peter. “A comparison of caffeine versus pseudoephedrine on cycling time-trial performance.” International Journal of Sport Nutrition and Exercise Metabolism, April 9, 2013. Accessed October 18, 2020. National Health Service. “Loratadine.” October 19, 2018. Accessed October 18, 2020. U.S. National Library of Medicine. “Claritin.” February 10, 2020. Accessed October 18, 2020. U.S. National Library of Medicine. “Claritin-D 12 Hour.” November 4, 2019. Accessed October 18, 2020. 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